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Prednisone to Prednisolone is impaired. Prednisone is the most commonly-prescribed oral corticosteroid. As side effects of this medicine. Prednisone is inactive in the body and, in order to be effective, first must be converted to Prednisolone by enzymes in the liver. Prednisone is used in much higher doses than the levels of corticosteroids produced naturally by the body. Before the needed effect is achieved. Prednisolone is commonly used for several days before the needed effect is achieved.
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