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Although some side effects can be serious. Keflex is effective antibiotic therapy for skin and skin structure infections and is the most commonly prescribed antibiotic for that reason. The usual recommended dosage of Keflex is 250 milligrams taken every six hours. Stopping the medication too early may allow bacteria to continue to grow resulting in a relapse of the infection. Cephalexin belongs to a class of antibiotics called cephalosporins. Take additional cephalosporin antibiotics as this is likely to result in an overdose. The effects of Cephalexin. Cephalexin may be given on an empty stomach or with food to prevent stomach upset. Cephalexin is contra-indicated in patients with known allergy to the cephalosporin group of antibiotics.