Beta-blockers work by blocking beta receptors that are found in various parts of the body. Several reports in the published literature describe cases in which Propranolol was used as a suicide agent. Beta-blockers work by blocking beta receptors that are found in various parts of the body. Propranolol may reduce the oxygen requirement of the heart and so decreases its demand for oxygen. Propranolol from Inderal capsules is almost completely absorbed from the gastrointestinal tract and undergoes extensive presystemic elimination due to its high hepatic clearance. Care should be taken if adrenaline is given with Propranolol, as this combination can cause severely high blood pressure and slow heart rate. Propranolol exerts ant arrhythmic effects in concentrations producing beta-adrenergic blockade, which appears to be its principal ant arrhythmic mechanism of action.
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