Propranolol may reduce the oxygen requirement of the heart at any level of effort by blocking catecholamine induced increases in the heart rate, low blood pressure and heart failure. Propranolol may reduce the oxygen requirement of the heart and so decreases its demand for oxygen. Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and systolic ejection period. Care should be taken if adrenaline is given with Propranolol, laboratory determinations should be made at regular intervals. Possible deleterious effects from long-term use of Propranolol have not yet been adequately appraised. Propranolol may reduce the oxygen requirement of the heart and so decreases its demand for oxygen.
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